Anandamine, or Why Cannabis Makes Us So Happy …

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Ananda-what? Anandamide It is also known as the “happiness molecule” in cannabis. This is also referred to as AEA by scientists. This natural cannabinoid – a neurotransmitter, in fact – contains the secret of joy that cannabis gives us. And for that, out of pure gratitude, we are putting him in the spotlight today!

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Cannabinoids are an exciting group of compounds. Over the years, many discoveries have been made by researchers or scientists who focus on cannabis research. Not only in relation to the cannabis plant, but also profiles of cannabis and terpenes, as well as their unique relationship with humans endocannabinoid system (ECS).

One of those narcotic substances that our body produces on its own are anandamides. Learn about anandamide and how it interacts with others cannabis reacts. And above all: the answer to the question of why anandamide is called the happiness molecule!

What is anandamide?

The human body is a complex whole. It makes substances that in turn react with what we add to them. This way we can happy correct under feel. Anandamide is a substance that can greatly contribute to our feelings of happiness.

This is the primary endogenous cannabinoid produced by the human body itself. The substance is not yet known, but what we know now is that this group of cannabinoids interacts well with other (plant) substances.

How did the name Anadamide come about?

The name “Anandamide” literally means “lucky molecule”. The word comes from Sanskrit. The word “Anand” literally means “happiness” or “joy”. “Amide” is a term describing the chemical formula of a molecule.

What makes anandamide so special?

Anandamide has unique properties and activities that help the ECS in our body to form a favorable relationship with cannabis plants. The substance was not discovered until the end of the 20th century (1992), around the time THC, CBD, and others appeared. phytocannabinoids It also gained fame.

Subsequently, scientific journals suggested that cannabinoids could bind to natural receptors in the human body to demonstrate their effects. Between 1990 and 1995, Dr. Rovil Meshulam And his research team succeeded in isolating anandamide from the human brain.

The endogenous cannabinoid neurotransmitter molecule anandamide… [beeld: StudioMolekuul/Shutterstock]

How does the body produce anandamide?

As mentioned, anandamide is naturally produced in small amounts in the human body. The production process is distributed across different molecular pathways using multiple enzymes. Anandamide has a relatively short half-life that begins with N-arachidonoylphosphatidylethanolamine (NAPE), which is the membrane precursor.

Half-life is the time when the amount of a substance is reduced to half its original value. This is done by dismantling it or turning it into other materials. In a concrete sense, this means that if anandamide is released into the body, it quickly disappears again.

What is the importance and function of anandamide?

The endocannabinoid system (ECS) mainly includes CB1– And CB2 receptors† Both receptors work with other factors to ensure that the homeostatic state of the body is maintained. Homeostasis is the body’s ability to maintain health by constantly restoring and balancing the internal or external environment, even as conditions change.

How does anandamine act?

The research team working on anandamide consists of Lumir Hanus, William Devane, and the aforementioned Dr. Mechoulam. They note that the happiness molecule behaves like THC. This is a rather complicated story but we try to keep it clear.

Both anandamide and THC have a strong binding interaction with cannabinoid receptors. Anandamide and THC are partial agonists of CB1 and CB2. This means that they are able to have effects on the central nervous system (CNS) and the immune system. However, THC has a stronger and more innate relationship with the CB1 receptor. Over a long period of time, THC induces multiple chemical effects.

In contrast, anandamide is weak. This is partly responsible for the fact that the happiness molecule cannot cause a significant psychological effect. It is instead responsible for generating feelings of pleasure, reward, inspiration or motivation. The places the brain is active are mainly in the areas related to memory, nutrition, learning, and movement. Scientists say that anandamide allows us to make or break down neutral compounds that enhance memory and learning.

The primary function of anandamide is homeostasis. The brain releases it regularly to keep the endocannabinoid system in good shape.

The combination of hemp and anandamine makes us very happy… [beeld: JosepPerianes/Shutterstock]

What is the relationship between cannabis and anandamide?

Hemp and anandamide have a unique and multifaceted relationship. Each cannabinoid in the cannabis plant has a different effect on the happiness molecule. Scientists would like to have more information about the results of THC and CBD on the AEA molecule. So there are still research opportunities here.

THC and AEA

THC And anandamide have similar profiles. Both are partial agonists of CB1 receptors and have recognizable chemical structures.

When the body breaks down THC, it continues to hijack CB1 receptors, resulting in a more profoundly dramatic response. This manifests itself as a psychological activity. THC gradually affects the functioning of the orbitofrontal cortex, hippocampus, basal ganglia, and cerebellum. The user may sometimes suffer from lack of coordination and short-term memory.

THC and AEA stimulate the release of dopamine, which makes you feel good. Dopamine is also involved in other actions such as sex, nutrition, and rewards.

The brain chemical dopamine is released when nerve cells transmit electrical signals to each other. The nature of the broadcast signal determines the choices you make in your daily activities. Without dopamine, you wouldn’t be able to consciously or unconsciously stimulate, learn, change moods, or maintain a healthy attention span.

It is important to know that infrequent use of THC in the short term directly affects the reward system in the brain. At least as long as the connection remains active. Periodic use of THC can relatively reduce the amount of dopamine produced, which reduces motivation and other negative emotions. Anandamide molecules are directly affected by:

CBD and AEA

CBD is the second notable plant-derived cannabis plant. It interacts with the enzyme FAAH (the chemical involved in breaking down AEA).

CBD is the main reason anandamide has a short half-life. CBD counteracts the effect of the chemical in the brain. CBD does this by stopping the breakdown of the FAAH enzyme.

Can we increase the availability of AEA in the body?

You can increase the amount of anandamide in the body in several ways. Of course, you can smoke weed or use food items that contain THC or other products such as CBD extract or oil.

Certain foods also increase the amount of the happiness molecule in your body. Think black truffles, chocolateBlack pepper and kaempferol. Certain activities can also stimulate production, such as exercise, hugging, yoga, cycling and long-distance running. Endurance activities in particular stimulate production.

Most importantly, eat substances that inhibit FAAH or contain large amounts of anandamide. For example, the body automatically contains an increased content of AEA.

What is coming down so far?

The researchers concluded that responsible cannabis use could contribute to a more open view of life in the long term. Scientific knowledge of anandamide and its relationship to cannabis has come a long way since the discovery of the first cannabinoids.

However, there is still a wealth of information to discover how cannabis and hemp plants can be maximized to help users feel happier in the long run.

Until then, you can of course continue to use THC-based products. Always remember that with more cannabis, endurance based exercise or activities, and a balanced meal, you will have more happiness or enjoyment with increased AEA levels.

[openingsbeeld: christopherbrownphotos/Shutterstock]

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